More young adults are developing osteoarthritis – here’s how we can spot those at risk before the damage is done

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Research suggests young, active people are increasingly being diagnosed with osteoarthritis at much earlier ages than many expect. I have seen its effects first-hand among my own friends. One, a keen marathon runner, developed stage 2 osteoarthritis in her mid-30s. Several well-known public figures, including Robbie Williams, Tiger Woods and Andy Murray, have also spoken openly about experiencing the condition relatively young.

Osteoarthritis is often dismissed as an inevitable consequence of ageing, but it can erode quality of life at any age. It can turn everyday activities such as walking, climbing stairs or exercising into painful challenges. More than 600 million people worldwide live with osteoarthritis, and its risk factors are varied. They include obesity, ageing, metabolic disorders, chronic inflammation, previous joint injury and repetitive mechanical stress.

For younger people, osteoarthritis can be particularly devastating. Pain and stiffness can limit physical activity during years when work, caregiving and family life are often most demanding. It can affect mental health, restrict career choices and reduce the ability to stay active, which in turn increases the risk of other long-term health conditions. Unlike older adults, younger patients may also face decades of managing symptoms and repeated treatments.

骨关节炎是 由于关节内起到缓冲作用的光滑软骨逐渐退化而引起的。软骨通常起到缓冲作用，使骨骼能够彼此顺畅地滑动。随着软骨的磨损，关节失去了这种保护。骨骼表面开始相互摩擦，导致疼痛、僵硬，以及 许多人戏称为“嘎吱嘎吱”的摩擦声或“咔嚓”声， 直到这种不适感变得无法忽视。

The condition does not appear overnight. Osteoarthritis usually takes years, and often decades, to develop. Early symptoms are often subtle and easy to dismiss: mild knee pain after activity, stiffness that eases with movement, or discomfort that comes and goes. Many people delay seeking medical advice until pain becomes persistent and joint damage is already advanced.

目前，治疗重点在于控制症状，而非逆转疾病本身。这包括运动疗法、止痛药和治疗性注射。

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这些注射疗法可能包括 富血小板血浆，它由患者自身血液的浓缩部分制成，含有被认为能促进组织修复的生长因子。其他疗法则使用 血小板衍生囊泡，这是一种由血小板释放的微小颗粒，能够携带参与炎症和愈合的生物信号。

However, most evidence for vesicle-based approaches currently comes from animal studies, including rat models, and they are not yet used routinely in human clinical practice. Hyaluronic acid may also be injected. This is a gel-like substance naturally found in joint fluid that helps lubricate and cushion the joint.

These treatments aim to reduce pain or improve joint movement rather than repair damaged cartilage. For some people, they provide temporary relief. Ultimately, however, when joint damage becomes severe, total joint replacement may be the only remaining option.

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Read more: Do you have knee pain from osteoarthritis? You might not need surgery. Here’s what to try instead

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But what if osteoarthritis could be detected much earlier, before pain and irreversible damage set in?

Early prevention and early intervention have the potential to reduce pain, preserve mobility and significantly lower healthcare costs. The challenge has always been identifying osteoarthritis early enough to act.

Early diagnosis

This is where emerging diagnostic technologies may eventually offer a breakthrough. Every chemical compound in the body has a unique molecular structure, and when analysed it produces a distinctive pattern known as a “spectral fingerprint”.

This fingerprint reflects the chemical composition of a sample, such as blood serum. In people with osteoarthritis, researchers have observed subtle changes in inflammation, metabolism and tissue turnover that may alter this chemical profile.

One way of studying these fingerprints is through a technique called attenuated total reflection Fourier-transform infrared spectroscopy. Despite the intimidating name, the principle is straightforward.

A small blood sample is exposed to infrared light, and the way that light is absorbed provides information about the types of molecules present. Changes in proteins, lipids and other biomolecules can leave measurable signatures, which researchers are investigating as potential indicators of osteoarthritis.

这些方法目前仍主要用于研究领域，尚未纳入常规临床诊疗。即便处于早期阶段，这项研究也意义重大，因为它最终可能有助于更早地识别骨关节炎风险，从而更有效地通过生活方式的改变和针对性的干预措施来保护关节健康。

By combining this approach with computational analysis, researchers can identify complex chemical patterns associated with disease. In practice, this means comparing blood samples from people with and without osteoarthritis and detecting differences that are invisible to the naked eye. Similar approaches can also be used with other laboratory techniques, including spectroscopy-based methods and molecular biology tools, to identify biomarkers linked to early joint disease.

This kind of early detection could transform how osteoarthritis is managed. Identifying risk before symptoms become severe would allow people to take action earlier, through targeted exercise, weight management, injury prevention and tailored treatment strategies.

Osteoarthritis does not have to mean decades of pain and limitation. By shifting the focus from late-stage treatment to early detection and prevention, it may be possible to change the trajectory of the disease and improve quality of life for millions of people worldwide.

Original Author:[By Atiqah Aziz]
Source:[THE CONVERSATION-https://theconversation.com/more-young-adults-are-developing-osteoarthritis-heres-how-we-can-spot-those-at-risk-before-the-damage-is-done-274451]

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